Science R & D

BIOSCIENCES

SERVICES AND RESOURCES

Analytical Tools (Web Portals)

Databases

Software (Downloads)

RESEARCH PROGRAMS

• Complex Systems
The Complex Systems group, led by Shankar Subramaniam, is engaged in providing the analytical infrastructure to integrate life sciences knowledge and achieve a global understanding of how living systems work as total entities, thereby discovering how the emergent properties of the assembled parts create biological functions. Integrating the analysis of heterogeneous data – the combination of proteomic, small molecule and transcriptional information along with legacy knowledge – creates the capability for quantitative and predictive modeling of biological functions, especially at the level of large cellular networks.

• Structural Bioinformatics
The Structural Bioinformatics group, led by Phil Bourne, develops and applies algorithms and methods to biological structures – proteins, DNA, RNA, ligands etc., and complexes thereof - to further our understanding of biological systems. The major part of this research uses the Protein Data Bank (PDB), the single worldwide repository for the processing and distribution of 3-D biological macromolecular structure data. The group is engaged in the study of signaling and apoptosis and the classification of protein fold space through structure alignment, as well as ontology development, homology modeling (including work on voltage gated channel proteins), protein functional annotation, data models, query languages and visualization tools.

• Next Generation Tools for Biology
The NGTB group is a software development program led by Dr. Mark Miller. The mission of this group is to develop flexible, enabling open source frameworks that provide work areas for scientists in Biology. The goal is to create virtual work areas where analytical tools, display tools and data are united in a user-friendly environment.

• Molecular Interactions and Crystallography
The focus of the research in the Molecular Interactions group, lead by Lynn Ten Eyck, is on theoretical and computational tools for predicting the interactions, dynamics, and functional properties of biological macro-molecules.